Dan,
I only took a quick look at it and at this point I only have one general piece of advice: I'd skip the politics! mainly because it's going to guarantee losing plenty of readers that would, otherwise, find your book useful.
Maybe write a different book on that?
Also, I see no good reason for excluding readers basically based on religion (re: Who is This Project Not For?) -- yeah, you'd expect logical people to find that evolution is a much more likely explanation for how we got here but that doesn't stop one of the major players in deciphering the human genome, for instance, from being a devout Christian. No need to be bringing that up, really (people have very strong private feelings about it whether it makes sense or not and would probably take offense).
The only traditionally verboten subject for public conversation you missed is sex. Although, you could have worked it in as a joke: "this book is not for prudes! and don't you dare read it..." :)
*kidding*
Delia
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